The Mureck 220 is situated in the northeastern part of Slovenia, close to the Austrian border. The road runs between the settlements of Selnica ob Muri and Sladki Vrh, both located within the Mura statistical region. This area is characterized by its proximity to the Mura River, which forms a natural border between Slovenia and Austria. The region is predominantly rural, with agricultural landscapes and small towns. The nearest larger settlement is Mureck, an Austrian town located just across the border. An interactive map showing the route of the Mureck 220 can be found at the end of this article.

The Mureck 220 extends for approximately 5.3 km (3.3 miles), offering a moderately twisty ride suitable for a range of motorcyclists. The road surface is asphalt and is generally rated as very good, providing a stable and predictable grip. The route features a mix of one-lane and two-lane sections, with about 45% of the road being single-lane and 27% double-lane. In terms of width, the majority (about 60%) is considered wide, while the remainder is of medium width. The elevation ranges from 256 m (840 ft) to 374 m (1,227 ft), with gentle undulations rather than steep climbs or descents. Approximately 36% of the route passes through inhabited areas, so riders should be mindful of local traffic and potential pedestrian crossings.

While the Mureck 220 itself is primarily a connector between rural settlements, the surrounding region offers several attractions. The nearby Mura River is notable for its natural beauty and biodiversity, attracting visitors interested in birdwatching and river-based activities. The town of Mureck is known for its historic watermill, which is a popular stop for travelers in the area. Additionally, the region is part of the Slovenian Styria wine-growing area, offering opportunities for wine tasting and local cuisine.

There are no known permanent closures for motorcycles on the Mureck 220. The road remains open throughout the year, as it does not traverse high-altitude or mountainous terrain that would typically require seasonal closures. However, riders should be aware that temporary closures may occur due to local events, roadworks, or adverse weather conditions, particularly during periods of heavy rain or flooding from the nearby Mura River. It is advisable to check local traffic updates before planning a ride.

The Mureck 220 does not currently require a toll or entrance fee for motorcycles or other vehicles. Riders should note that toll conditions may change in the future, and it is recommended to consult official resources for the most up-to-date information. For comprehensive details on road tolls and vignettes in Slovenia, visit the DARS Motorway Company website. Standard speed limits apply, with most sections limited to 50 km/h (31 mph) in inhabited areas and up to 90 km/h (56 mph) in rural stretches, unless otherwise indicated by local signage.